Panther Creek is one of the major drainages of the Salmon Mountains. You can take the road from Panther Creek through Colbalt to Challis, Idaho. You can read about this area in the book Walking Without Footprints.
The Outpost is a small pub on the confluence of Panther Creek and the Salmon River. The outpost has a landing dock; so you can plan a hot lunch for boating excursions.